Monitor Carefully (one)mitotane decreases amounts of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Mitotane is a powerful inducer of cytochrome P-4503A4; keep an eye on when coadministered with CYP3A4 substrates for attainable dosage adjustments. omaveloxolone will decrease the extent or result